LIBS Info: Element Analysis
| Title | Authors | Material | Detector | Spectrometer | Software |
|---|---|---|---|---|---|
| Quantitative analysis of pharmaceutical products by laser-induced breakdown spectroscopy | L. St-Onge , E. Kwong, M. Sabsabi, E.B. Vadas | Pharmaceuticals | Not Known | Not Known | |
| Laser: | Nd:YAG 1064.0000nm 75.0000mJ 2.000Hz |
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| Gate Delay: | Noneus | ||||
| Gate Width: | Noneus | ||||
| LIBS Analysis in pharmaceutical applications is the primary focus of this paper. However, it contains one of the few LIBS investigations of halogens available in the literature. Pharaceutical analysis by LIBS is usually not of the active ingredient (as it can't determine the molecular structure well), but of a tagging element (Cl, S, F, Br, Na, K, Mg, P or Ca). | |||||
| Element | Detection Limit (ppm) | Wavelength (nm) | Other Wavelengths (nm) | Calibration Method | Calibration Range (ppm) | Notes |
|---|---|---|---|---|---|---|
| P | 50.0000 (Stated) | 253.5000 | N/A | Univariate Calibration | 0.0000-9500.0000 | Peak analysed was actually an unresolved doublet (253.4nm and 253.57nm). Improved reproducibility was achieved by a ratio to C I at 247.86nm. |
| Cl | 600.0000 (Minimum concentration detected) | 837.5900 | N/A | Univariate Calibration | -10.0000--10.0000 | Reproducibility improved by ratio to C I peak at 833.52nm. Results also improved by flowing He over analysis surface. LOD not stated in the paper, but calculated from calibration curves (and ratio's of active ingredient to Cl concentration quoted). |
| F | 1350.0000 (Minimum concentration detected) | 685.6000 | N/A | Univariate Calibration | -10.0000--10.0000 | Significantly lower RSDs achieved by ratioing to background signal. Improvement in detection limits due to flowing He over the sample also noted. LOD not stated in the paper, but calculated from calibration curves (and ratio's of active ingredient to Cl concentration quoted). |
| Element | RMSE (ppm) | Wavelength (nm) | Calibration Method | Notes |
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