LIBS Info: Element Analysis

Title Authors Material Detector Spectrometer Software
Quantitative analysis of pharmaceutical products by laser-induced breakdown spectroscopy L. St-Onge , E. Kwong, M. Sabsabi, E.B. Vadas Pharmaceuticals Not Known Not Known
Laser: Nd:YAG
1064.0000nm
75.0000mJ
2.000Hz
Gate Delay: Noneus
Gate Width: Noneus
LIBS Analysis in pharmaceutical applications is the primary focus of this paper. However, it contains one of the few LIBS investigations of halogens available in the literature. Pharaceutical analysis by LIBS is usually not of the active ingredient (as it can't determine the molecular structure well), but of a tagging element (Cl, S, F, Br, Na, K, Mg, P or Ca).
Element Detection Limit (ppm) Wavelength (nm) Other Wavelengths (nm) Calibration Method Calibration Range (ppm) Notes
P 50.0000 (Stated) 253.5000 N/A Univariate Calibration 0.0000-9500.0000 Peak analysed was actually an unresolved doublet (253.4nm and 253.57nm). Improved reproducibility was achieved by a ratio to C I at 247.86nm.
Cl 600.0000 (Minimum concentration detected) 837.5900 N/A Univariate Calibration -10.0000--10.0000 Reproducibility improved by ratio to C I peak at 833.52nm. Results also improved by flowing He over analysis surface. LOD not stated in the paper, but calculated from calibration curves (and ratio's of active ingredient to Cl concentration quoted).
F 1350.0000 (Minimum concentration detected) 685.6000 N/A Univariate Calibration -10.0000--10.0000 Significantly lower RSDs achieved by ratioing to background signal. Improvement in detection limits due to flowing He over the sample also noted. LOD not stated in the paper, but calculated from calibration curves (and ratio's of active ingredient to Cl concentration quoted).


Element RMSE (ppm) Wavelength (nm) Calibration Method Notes